Heart Disease and Stroke Research

Heart Disease and Stroke Research Laboratories

Lymphatic Development Laboratory

The Lymphatic Development Laboratory performs research to understand how the growth and development of lymphatic vessels (lymphangiogenesis) is controlled during embryonic development and in disease states.

Name A/Prof Natasha Harvey
Telephone +61 8 830 27835
Email natasha.harvey@unisa.edu.au
Website Centre for Cancer Biology: Lymphatic Development Laboratory


Molecular Signalling Laboratory

The Molecular Signalling Laboratory examines cell signalling pathways that contribute to cancer and other diseases. In particular, the primary focus of our work is on the sphingolipid pathway, which can trigger increased cell survival, increased cell proliferation, and new blood vessel formation; three of the classic hallmarks of cancer. Indeed, we and others have established that sphingosine kinase, a central enzyme in the sphingolipid pathway, plays an important role in many different cancers, and is an attractive target for anti-cancer therapy. Our studies are directed in 3 main areas: (i) to understand the molecular mechanisms regulating sphingosine kinase in cancer, (ii) developing agents that target sphingosine kinase, or its regulation, as anti-cancer agents, and (iii) defining the downstream pathways important for sphingolipid-mediated cancer cell signalling.

Name Prof Stuart Pitson
Telephone +61 8 830 27832
Email stuart.pitson@unisa.edu.au
Website Centre for Cancer Biology: Molecular Signalling Laboratory


Vascular Biology and Cell Trafficking Laboratory

Dr Claudine Bonder is a Heart Foundation Fellow and Head of the Vascular Biology and Cell Trafficking Laboratory at the Centre for Cancer Biology in Adelaide, South Australia.

From her research training during her PhD at Flinders University and post-doctoral position at the University of Calgary (Canada) she has gained expert experience in vascular and cellular biology, immunology, inflammation and imaging.

The focus of Dr Bonder’s laboratory is the blood vasculature and how it contributes to health and disease. More specifically, she and her team investigate (i) endothelial progenitor cells, (ii) leukocyte trafficking and (iii) activation of the vasculature during diseases such as heart disease, breast cancer, melanoma and allergy. Dr Bonder’s research has culminated in important advances in this area, including (i) identifying the adhesion molecules used by leukocyte subsets and progenitor cells to traffic to inflamed organs, (ii) defining mediators of endothelial progenitor cell function and differentiation and (iii) identifying key surface expressed receptors which regulate major cell survival signals.

Name A/Prof Claudine Bonder
Telephone +61 8 830 27833
Email claudine.bonder@unisa.edu.au
Website Centre for Cancer Biology: Vascular Biology Laboratory